Ankylosing Spondylitis – AS

The cohort supports research into Ankylosing Spondylitis (AS), a chronic arthritis that affects parts of the spine. Estimates of different European populations suggest that Ankylosing Spondylitis may affect between 2-5 adults in every 1,000. In the UK, around 200,000 people have been diagnosed with Ankylosing Spondylitis.

By studying a large number of individuals with the disease, the group aim to identify important genetic factors, find novel mechanisms involved in the development of AS, facilitate earlier diagnosis through genetic testing, and find new targets for treatments by facilitating research and clinical trials.

Resource Details

  • Currently a sample size of over 3,500 individuals with AS.
  • Bloods and DNA samples.
  • Associated Data Sets = Demographic, Clinical plus UK GWAS data (n = 4500).


For more information please contact Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, OXFORD, OX3 7HE. Tel: +44 (0)1865 227374. The resource is led by Prof. Paul Wordsworth