Oxford Gastrointestinal Illness Biobank

The Oxford Gastrointestinal Illness (GI) Biobank was created to support translational research by collecting biological samples and associated data from patients undergoing assessment and treatment for GI disease. By prospectively studying a large number of patients, researchers hope to identify exposure factors important in the development and clinical course of the disease, and progress towards finding novel approaches to treatment and management. The resource is led by Dr Satish Keshav, Chief Investigator and Consultant Gastroenterologist.

The GI Biobank was strongly supported by the Translational Gastroenterology Unit (TGU), a state-of-art unit situated in the John Radcliffe Hospital with the purpose of running clinical programmes in close proximity to cutting edge research. Key targets for studies include establishing the natural history and evolution of GI disease, identifying features and biomarkers that improve diagnosis and treatment, and determining better ways to measure clinical outcomes and the cost of care.

The Inflammatory Bowel Disease (IBD) cohort is an important facet of the GI Biobank, focusing studying patients with Crohn's disease and ulcerative colitis over time, so that biomarkers and other important prognostic features can be identified. 

Resource Details

  • Biological samples and data obtained from patients with GI disease.
  • Samples of DNA, serum, plasma and other body fluids, primary cells, cell lines and tissue samples.
  • Detailed characterisation of patients for stratification and subgroup analyses such as physiological function, immunological and histopathology markers.

Access

The GI Illness Biobank is available to researchers internal and external to Oxford on successful application. An internal board within the TGU assesses applications and determines whether they are appropriate and within the limits of the ethical approval. The use of the biobank must be acknowledged in any published outputs. For more information contact Dr. Carolina Arancibia.