Quality in Organ Donation – QUOD

Funded by NHSBT, this is a National Consortium of all National Organ Retrieval teams collecting biological samples and data from deceased organ donors in the UK. QUOD specific research consent is obtained by the Specialist Nurses in Organ Donation and sample collection takes place at different stages of the donor management period.

Resource Details

  • Sample collection consisting of:
    • Blood and urine samples taken at four time points during the organ donor management period and tissue biopsies taken after organs are retrieved and before transplantation.
  • Sample formats:
    • Blood sets: in 0.5ml aliquots stored at -80°C, plasma (EDTA), plasma (Heparin) and serum (SST).
    • Urine in 1ml aliquots, stored at -80°C, centrifuged urine.
    • Tissue sets: snap frozen, stored in vapour phase liquid nitrogen (-196°C) kidney needle core biopsies, liver needle core biopsies, ureter biopsies and spleen biopsies. 
    • Tissue sets: formalin fixed paraffin embedded tissue blocks, kidney needle core biopsies, liver needle core biopsies and ureter biopsies.
  • Access to anonymised data related to the samples and clinical data from the organ donor.
  • Access to post transplant clinical data from matching transplant recipients.
  • Ethical approval for research projects aiming to improve quality in organ donation.
  • We are planning to develop an image library of all formalin fixed paraffin embedded tissue blocks stained with the standard H&E stain; this is currently in development.

Access 

Further information regarding the procedure to apply for access to QUOD samples can be found in the 'For Researchers' section of the QUOD website.  All applications for access to resources are considered by the QUOD Steering Committee and should be forwarded to the QUOD team via contact@quod.org.uk  

Contact

For additional details please contact the QUOD team contact@quod.org.uk. The coordinating Principal Investigator is Rutger Ploeg, Professor in Transplant Biology and Consultant Transplant Surgeon.